Isotopically Labeled Compounds
Medchemexpress LLC Tiopronin-d3 | 1189700-74-0 | 99.4% | 1 MG
Tiopronin-d3 is the deuterium labeled Tiopronin. Tiopronin acts as a diffusible antioxidant, an antidote to heavy metal poisoning, and a radioprotective agent. It can regulate the rate of cystine precipitation and excretion, showing potential for treating cystinuria, rheumatoid arthritis, and hepatic disorders. For research use only.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Medchemexpress LLC Sorafenib-d3 (Donafenib; Bay 43-9006-d3) | 1130115-44-4 | 99.57% | 467.84 | 25 MG
Sorafenib-d3 (Donafenib) is a deuterated compound of Sorafenib, recognized as the first deuterium-generation tumor suppressor small molecule. Sorafenib itself is a multikinase inhibitor with IC50s of 6 nM for Raf-1, 20 nM for B-Raf, and 22 nM for VEGFR-3. This compound is intended for research use only. Potential advantages of deuterated compounds like Sorafenib-d3 include:
- Extends the in vivo half-life.
- Improves oral bioavailability.
- Enhances metabolic characteristics.
- Improves drug safety.
- Preserves therapeutic properties.
Medchemexpress LLC Zoledronic acid-d3 (zoledronate-d3) | 1134798-26-7 | 275.11 | 1 MG
Zoledronic acid-d3 (Zoledronate-d3) is the deuterium labeled Zoledronic acid. Zoledronic Acid (Zoledronate) is a third-generation bisphosphonate (BP), with potent anti-resorptive activity. Zoledronic Acid inhibits the differentiation and apoptosis of osteoclasts. Zoledronic Acid also has anti-cancer effects.
- This compound can be used as a tracer.
- This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Deuteration has potential to affect the pharmacokinetic and metabolic profiles of drugs.
Medchemexpress LLC L-lysine-13C dihydrochloride | 202190-50-9 | 99.9% | 220.10 | C5(13C)H16Cl2N2O2 | 10 MG
L-lysine-13C dihydrochloride is a stable-isotope labelled form of the essential amino acid L-lysine, provided as the dihydrochloride salt for tracer, metabolic, and mass-spectrometry studies. It is 13C-labelled at the carboxyl carbon and supplied as a white to off-white solid with high chemical purity.
- 13C-labelled at the carboxyl carbon for tracer and mass-spectrometry applications.
- Provided as the dihydrochloride salt for improved solubility and stability.
- High purity (99.9%) suitable for research use.
- White to off-white solid; molecular weight 220.10 g/mol.
- CAS number 202190-50-9 for unambiguous identification.
- Storage: store sealed at 4°C; in solvent, store at -80°C (6 months) or -20°C (1 month).
Cambridge Isotope Laboratories METHANOL (13C, 99%), 5 G, 14742-26-8
METHANOL (13C, 99%), 5 G, 14742-26-8
Cambridge Isotope Laboratories DEUTERIUM HYDRIDE (D, 97%), 5 L, 13983-20-5
DEUTERIUM HYDRIDE (D, 97%), 5 L, 13983-20-5
Medchemexpress LLC Lofexidine-d4 hydrochloride | 1206845-57-9 | 1 MG
Lofexidine-d4 hydrochloride (Baq-168-d4) is the deuterium labeled Lofexidine hydrochloride. Lofexidine hydrochloride is a selective α2-receptor agonist, commonly used to alleviate the physical symptoms of heroin and other types of opioid withdrawal. It is for research use only and not sold to patients. This compound can be used as a tracer and as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process
- Deuteration has the potential to affect the pharmacokinetic and metabolic profiles of drugs
Medchemexpress LLC 1-Adamantan-d15-amine | 33830-10-3 | MFCD01317436 | 98.0% | 166.34 | C10H2D15N | 10 MG
Amantadine-d15 (1-Adamantanamine-d15) is the deuterium-labeled isotopologue of amantadine supplied as a solid analytical standard for use in mass spectrometry, isotope-dilution quantitation, metabolic, and pharmacokinetic studies. The product is characterized by its molecular formula and verified purity on the certificate of analysis, and is intended for use as an internal standard or tracer in quantitative workflows.
- High isotopic labeling suitable for mass spectrometry applications.
- Purity 98.0% as reported on the certificate of analysis.
- White to off-white solid for convenient storage and handling.
- Appropriate as an internal standard for LC-MS/MS and GC-MS quantitation.
- Provided in a 10 mg quantity for analytical use.
Medchemexpress LLC Squalene-d6 | 1875101-86-2 | 416.75 | 5 MG
Squalene-d6 (Super Squalene-d6) is a deuterium labeled Squalene. Squalene (Super Squalene) is an intermediate product in the synthesis of cholesterol, and shows several pharmacological properties such as hypolipidemic, hepatoprotective, antiatherosclerotic, cardioprotective, antioxidant, and antitumour activity.
- This compound can be used as a tracer.
- This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Medchemexpress LLC Uric acid-1,3-15N2 | 62948-75-8 | MFCD00145511 | 99.6% | 170.10 | C5H4N4O3 (1,3-15N2) | 10 MG
Uric acid-1,3-15N2 is a 15N-labeled uric acid supplied as a high-purity solid for use as an isotopically labeled internal standard in analytical and biochemical workflows. It is intended for quantitation, tracer studies, and method development in mass spectrometry and related techniques.
- Purity 99.6% for analytical accuracy.
- Includes 10 mg of solid material.
- Molecular weight 170.10 for mass spectrometric reference.
- 1,3-15N2 labeling enables tracer and quantitative studies.
- White to off-white solid appearance, suitable for standard analytical handling.
- Recommended storage: powder at -20°C for long-term stability.
Medchemexpress LLC Bis(2-ethylhexyl) phthalate (deuterated) | 352431-42-6 | 428.79 | C24D38O4 | 10 MG
DEHP-d38 is the deuterium-labeled form of bis(2-ethylhexyl) phthalate used as an analytical standard and tracer in mass spectrometry and quantitative studies. Supplied in a small research-scale package, it facilitates accurate quantification and recovery experiments where isotopic labeling improves analytical precision.
- Deuterium-labeled internal standard for mass spectrometry.
- Molecular formula C24D38O4, molecular weight 428.79, CAS 352431-42-6.
- Liquid, colorless to light yellow appearance.
- Stable under recommended storage: -20°C for long-term; -80°C in solvent for short-term.
- Available in small research quantities, including 10 mg packages.
Medchemexpress LLC DL-alanine-d3 | 53795-94-1 | MFCD00084106 | 98.0% | 92.11 g/mol | C3H4D3NO2 | 10 MG
DL-Alanine-d3 is a deuterium-labeled form of the amino acid alanine provided as a solid for analytical and tracer applications. It is used as an internal standard and isotopic tracer in mass spectrometry, metabolomics, and method development where precise quantitation and tracking of alanine are required.
- Deuterium-labeled analog for use as an internal standard.
- High chemical and isotopic purity suitable for quantitative analysis.
- Available in small, premeasured amounts for analytical workflows.
- Suitable for mass spectrometry, metabolomics, and tracer studies.
- Stable solid form for straightforward storage and handling.
Medchemexpress LLC Melperone-d4 hydrochloride | 1219798-80-7 | 99.8% | 1 MG
Melperone-d4 hydrochloride is a deuterium-labeled form of Melperone hydrochloride, a butyrophenone with atypical antipsychotic properties. It functions as a multireceptor antagonist, targeting 5-HT2A, dopamine D2, α1-adrenergic, and α2-adrenergic receptors, along with weaker binding to other receptors. It also inhibits CYP2D6. This compound is valuable for research into schizophrenia and agitation in the elderly.
- Deuterium-labeled compound
- Atypical antipsychotic properties
- Functions as a multireceptor antagonist
- Targets 5-HT2A, dopamine D2, α1-adrenergic, and α2-adrenergic receptors
- Inhibits CYP2D6
- Useful for research on schizophrenia and agitation in the elderly
- Can be used as a tracer
- Suitable as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Cambridge Isotope Laboratories SODIUM L-LACTATE (3-13C, 98%) 20% W/W IN H2O, 1 G OF C, 201595-70-2
SODIUM L-LACTATE (3-13C, 98%) 20% W/W IN H2O, 1 G OF C, 201595-70-2